Dr. Gao Ran, a PhD candidate at Capital Medical University in Beijing specializing in neuroimmunology, focuses her research on the mechanisms of action and clinical therapy between microglia and neurodegenerative diseases in this abstract. In the context of chronic neuroinflammation, the polarization and metabolic changes in microglia become increasingly pronounced. This article aims to summarize the key roles of metabolic reprogramming and polarization in microglial function, as well as their implications in major neurodegenerative diseases. The findings hold significant clinical relevance, particularly in the field of neurological disorders.

Stefano Sandrone is an Italian neuroscientist and an educationalist working at Imperial College London. He won the Science Educator Award presented by the Society for Neuroscience and the B. Baker Teacher Recognition Award from the American Academy of Neurology twice. He wrote three books, including Nobel Life, where he interviewed 24 Nobel Laureates on their Life stories, advice for future generations and what remains to be discovered.

Zhonghua Xiong, PhD. Doctoral student at Capital Medical University, China, with four SCI papers published as first or co-first author. Serves as a Guest Editor for the Special Issue "Emerging Treatments for Primary and Rare Headaches" in Frontiers in Neurology and presented at the 21st International Headache Congress. Research areas include clinical and basic research on epilepsy and primary headaches

He has 30 years’ experience in transfusion medicine, most of the time as expert in clinical transfusion but with very good experience in therapeutic apheresis and donor apheresis, as well as, blood component therapy. From few years ago introduced irradiation of blood components in Serbia, in Novi Sad, and most of the blood components that are irradiated are for oncology, hematology, in adults and children. He is more than 15 years dealing with Siberian natural products, some Chinese, one African and one South American. All are extremely effective and helpful. This is his experience in all this together.

Yujie Bo, PhD, Doctor Currently, I am a PhD candidate in the Department of Neurosurgery at the Sanbo Brain Hospital, affiliated with Capital Medical University, under the mentorship of Professor Guoming Luan, a renowned neurosurgery expert in China. I am currently dedicated to studying the pathological mechanisms of a rare disease, Rasmussen's encephalitis (RE), and its inflammatory response mechanisms, with the goal of identifying potential therapeutic targets for future treatments.

Jose Luis Gómez-Ariza is full professor of Analytical Chemistry and member of the Research Center for Natural Resources Health and the Environment of the University of Huelva (Spain). Member of the Spanish Society for Analytical Chemistry (SEQA) and the Academy of Sciences, Arts and Letters of Huelva. In 2003 received the Andalusia Research Award and the Huelva Industry Excellence Award. In 2022 has received the Gold Medal of the University of Huelva. He is the author or co-author of over 300 scientific publications (h-index 46), several books and book chapters, as well as over 600 contributions to scientific conferences, he also holds several patents. Over 35 students have received doctorates under his direction.

Torbjörn Bäckström, MD and PhD, senior professor at the Department of Clinical Science, Obstetrics and Gynecology, Umeå University as well as head of the Umeå Neurosteroid Research Center, started Umecrine Mood together with the Karolinska Institutet innovation system in 2006 and the company became Asarina Pharma in 2015. Professor Bäckström's main focus of research since 1972 is the effect of sex and stress hormones on the brain and in particular on the GABA-system, and conditions induced by these hormones. He has published more than 400 scientific publications within this area and he is a frequently invited key-note speaker at scientific meetings around the world. In 1989 professor Bäckström served several years on the scientific advisory board of the pharmaceutical company, CoCensys in the US, a company based on his own and the research of professor Kelvin Gee from University of California. Several active compounds were developed and one of these is currently in phase III of clinical development. CoCensys, was listed on the NASDAQ stock market until 1994, when it was sold to a larger pharmaceutical company.

Dr. Hari Shanker Sharma is Professor of Neurobiology (MRC) and Docent in Neuroanatomy (UU) at the Department of Surgical Sciences, Uppsala University Hospital (Sweden). He obtained his Master’s Degree from Bihar University with special expertise in Cell Biology in 1976. Dr Sharma obtained his Doctor of Philosophy Degree (D.Phil.) in Neurosciences and was awarded his Ph.D in 1982 from Banaras Hindu University. After carrying out a series of Government of India-funded Research Projects on the Blood Brain Barrier (BBB) and brain dysfunction, Dr Sharma joined the lab of Neuropathology at Uppsala University, with Professor Yngve Olsson, to investigate passage of tracer transport across the BBB, caused by stress to the brain and spinal cord. In 1991, Dr Sharma was awarded the prestigious Alexander von Humboldt Foundation Fellowship of German Government for his work on hyperthermia-induced BBB dysfunction at the ultrastructural level in the laboratory of Professor Jorge Cervós-Navarro. Currently, his main research interest is Neuroprotection and Neuroregeneration in relation to the BBB in stress, trauma, and drugs of abuse in health and disease. Dr Sharma has published over 380 articles, 12 monographs and 70 international book chapters, and he has edited 15 book volumes.

Professor Luiz Moutinho (BA, MA, PhD, MAE, FCIM) is a Fellow and Visiting Professor of Marketing at Suffolk Business School, Faculty of Arts, Business and Applied Social Science, University of Suffolk, Ipswich, England, UK, and at The Marketing School, Portugal and Adjunct Professor of Marketing, Graduate School of Business, Faculty of Business and Economics, University of the South Pacific, Suva, Fiji. In 2020 he was elected as the member of The Academia Europaea. In 2017 he received a degree of Prof. Honoris Causa from the Univ. of Tourism and Management Skopje, North Macedonia. During 2015 - 2017 he was professor of BioMarketing and Futures Research at the DCU Business School, Dublin City University, Ireland. This was the first Chair in the world on both domains - BioMarketing and Futures Research. Previously, and for 20 years, he had been appointed as the Foundation Chair of Marketing at the Adam Smith Business School, University of Glasgow, Scotland. Previously, he got his first Chair in 1989 at the University of Wales College of Cardiff 1989-2006. Professor Moutinho completed his PhD at the University of Sheffield in 1982. He has been a Full Professor for 34 years and has held Visiting Professorship positions at numerous universities worldwide. He is the Founding Editor-in-Chief of the Journal of Modelling in Management (JM2) and Co-editor-in-Chief of the Innovative Marketing Journal. His main areas of research interest encompass marketing, management and tourism futurecast, artificial intelligence, biometrics and neuroscience theory, evolutionary algorithms, human-computer interaction, the use of artificial neural networks in marketing, modelling processes of consumer behaviour, futures research. Prof. Moutinho has given keynote speeches, lectures, seminars, talks, etc. in 46 countries worldwide. Prof. Moutinho has 38 books published, over 159 articles published in refereed academic journals. He has 16250 academic citations, the h-index of 59 and the i10-index of 160 (Google Scholar, August 12th, 2023).

Professor Qingping Xie is a pioneering figure in the field of neurodegenerative disease surgery, renowned for his innovative surgical methodology, Deep Cervical Lymphaticovenous Anastomosis (LVA), developed at Hangzhou Qiushi Hospital. This avant-garde technique is designed to create a pathway for the efficient removal of toxic protein accumulations from the brain, addressing a fundamental mechanism behind Alzheimer’s disease and other neurodegenerative conditions. A breakthrough feature of Professor Xie's method is its surgical site—an extracranial area on the side of the neck—making the procedure significantly less invasive and enhancing its safety profile. Leveraging the anatomy of the lymphatic system, Professor Xie identified the V subdivision in the neck as the primary exit for brain lymphatic vessels, allowing for strategic augmentation of the lymphatic drainage system. Since its inception in late 2019, this procedure has shown remarkable efficacy, with over 400 cases performed on patients with Alzheimer's disease (approximately ) and other brain degenerative disorders, including Parkinson’s, ALS, and stroke, in China. Nearly all patients have reported immediate and lasting improvements in cognitive, motor, and memory functions following the procedure, representing a transformative advancement in treatment options for these conditions.

Kadir Uludag holds Ph.D. in Applied psychology (Chinese Academy of Sciences). He is currently doing postdoc in Shanghai Jiaotong University Mental Health Center. His research interest includes schizophrenia research, drug addiction and educational psychology. In addition, he runs a website to share and comment on peer-reviewed articles (ifx0.com).

Dr. Michelle Melgarejo da Rosa is working as a full-time Associate Professor of Biochemistry at Federal University of Pernambuco UFPE, Brazil. Dr. Michelle Melgarejo da Rosa received her Ph.D in the field of the molecular mechanism of Brain Synaptic Plasticity and Homeostatic Synaptic Plasticity, 2016 from Leibniz Institute for Neurobiology, Magdeburg, Germany. Dr. Michell worked as researcher at the Center for Therapeutic Innovation - NUPIT/UFPE. Dr. Michelle Melgarejo da Rosa is currently working on influence of molecules (natural products, galectinas, lectinas) on memory consolidation and aging.

Research Secretary, Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine,Uppsala University Hospital, SE-75185, Uppsala, Sweden

Ann Marie O’Connor is an Education Assistant for Grades K-12, where she works primarily with students who suffer from FAS/ ADHD and ODD. She is also a Canadian Advocate for Epilepsy and former Vice President for the Edmonton and Northern Alberta Epilepsy Association, where she was on the Board of Directors for over 11 years. She has published two books and had several articles written on her behalf (Surgical Neurology International/Your Health Magazine/Spruce Grove Examiner) as well as she has been interviewed on Global Edmonton and Breakfast Television Edmonton. Her topics of discussion are Women and Epilepsy-Sex and Seizures-Depression-Side effects of R-Her surgery-Books published. In Canada alone, an average of 42 people a day learn that they have Epilepsy and over 50 million people worldwide suffer from the disorder. I can say that I Beat Epilepsy. It was 6:30 AM on December 03, 2002. I remember being wheeled down the hall at the University of Alberta Hospital in Edmonton, Alberta, Canada by the porter with the silence it felt like we were the only ones in the building. You could hear a pin drop. I had lived with epilepsy for almost 20 years of my life and that was about to change. Left selective Amygdalohippocampectomy is the surgery I was about to undergo and it is what cured me of my seizures. The left parahippocampal gyrus, left amygdale and left hippocampus were removed; structures within the left temporal lobe. I had 6 seizures 2 days before the surgery and I have not had one since. Since my surgery, I have accomplished some amazing tasks in my life. I have written two books, was asked to be a Canadian Advocate for Epilepsy in 2012 and have been a motivational speaker for over 8 years. Helping others is my passion, is my calling. I want to educate others internationally from a patient’s point of view, help them understand that they are not alone when it comes to living with epilepsy

Sherronda Jamerson obtained a master’s degree in clinical psychology in 2012 from City University College in Seattle, WA, and became certified as a Chemical Dependency Professional in 2007. Her experiences include developing, implementing, and presenting EDI trainings to associations of healthcare professionals, healthcare providers, schools, and community-based organizations. She has also presented at state and national behavioral health conferences on the topics of DEI and Healthcare Equity. She presents with confidence and passion

Epilepsy is a neurological disorder characterized by recurrent seizures, which can affect individuals’ daily lives significantly. Understanding the public’s knowledge, attitudes, and practices (KAP) towards epilepsy is crucial for effective health education and management strategies. This study aimed to assess the perception, attitude and practice among a rural population in Sudan towards epilepsy. Method and Materials: This study was a descriptive cross-sectional, community-based study conducted in March 2023 at a rural area in Gezira state in the central part of Sudan. A self-constructed questionnaire was designed by authors based on revision of previous similar studies. It consisted of four domains: The first domain was about sociodemographic data (age, gender, occupation, residence and educational level). The second, third and fourth domains consisted of questions regarding knowledge, attitude and practice. 150 participants were involved in this study and data was analysed by SPSS version 22. Results: The total number of participant in this study was 150 individuals. The majority (83) were females (55.3%) and 36% of respondents were in the age group (15-30). The overall net result of KAP of the participants in this study towards epilepsy was as follows: for knowledge it was 67.9%, attitude 63.5% and practice 53.9%. There was no significant association between gender and knowledge of epilepsy, P-value 0.887. Conclusion: The current study’s findings underscore the need for targeted educational interventions to dispel myths and misconceptions about epilepsy. Increasing awareness through community-based programs can help reduce the stigma and improve the quality of life for epileptic individuals. Comparative analysis with other studies highlights the universal challenge of epilepsy-related stigma and the critical role of education in mitigating its impact.

Florent Pirot is a multidisciplinary researcher with Einstein Syndrome and specialties in geophysics, nuclear physics, astrophysics as well as biology and health. He got his graduate in economics and political sciences (Sciences Po Lille, College of Europe and CAPES in economics and sociology).

Medical Specialist in Emergency Medicine San Francisco University of Quito (2007 to 2012) Master's Degree in Occupational Health Gabriel René Moreno Autonomous University (2020 to 2021) Diploma in Clinical Toxicology Andrés Bello Catholic University (2022 to 2022) Medical Specialist in Emergency Medicine Calderón Teaching General Hospital Carlos Andrade Marín Hospital Oskar Jandl Hospital Vozandes Hospital Los Valles Hospital Inglés Hospital DAME Clinic University Professor Central University of Ecuador Equinoccial Technological University

Mikołaj Stańczak. Student of Medicine: former at Bari Aldo Moro, currently at Poznan University of Medical Sciences (MD) and Sports Rehabilitation: at AECC University College (MSc). Passionate about neurophysiology, motor control after orthopedic injuries, sports medicine, mechanobiology and cell biology. Former Strength and Conditioning Coach and Rehabilitator of at the central level in Poland and Italy of teams such as: SSC Bari - football, Chrobry Głogów - football, Siódemka Miedź Legnica – handball, SPS Chrobry Głogów- volleyball, KS Futsal Leszno - futsal. Currently Sports Rehabilitator at Austrian National Team and VALD ambassador (world leader at Sports Science Technologies). Currently a lecturer at the well-known RTS after ACLR course in Poland and academic lecturer in Józef Piłsudski University of Physical Education. Having dealt with sport in practice and its requirements for maintaining the health of players during the season, he began medical studies to better understand the molecular reactions mediating the adaptation of soft tissues to external loads, and therefore the etiology of musculoskeletal injuries. Participant of an numerous training courses and webinars ISAKOS (International Society of Arthroscopy, Knee Surgery and Orthopedic Sports Medicine), ESSKA (European Society of Sports Traumatology, Knee Surgery & Arthroscopy), AOSSM (American Orthopedic Society for Sports Medicine), NSCA (National Strength and Conditioning Association), MCI (Motor Control Institute) and ISMC International Society of Motor Control). Active lecturer at numerous conferences, trainings and online lectures (e.g Isokinetic Conference, Madrid 2024, Joint Preservation Congress, Warsaw 2024). In the future, he plans to combine common aspects of motor preparation, specialized sports rehabilitation with modern orthopedics and orthobiology.